Endocrine Abstracts

Purpose: The purpose of this study were to evaluate the relation thyroid autoimmunity and euthyroid hashimoto thyroiditis in patients diagnosed with pituitary adenoma and association of pituitary adenoma with clinical and laboratory findingsMaterials and methods: The retrospective study population included a total of 230 participants. A total of 189 patients (67 with prolactinoma, 35 with acromegaly, 4 with cushing disease and 83 with non-functional pitu...

Aim: We report a child with reactive pituitary enlargement and microadenoma due to Hashimoto thyroiditis.We want to emphasize the importance of good endocrine evaluation in pediatric cases of pituitary adenomasCase report: A 7 year 7 month old boy presented with mild symptoms of hypothyroidism. There was no feature in his past medical story.He had normal cognitive and neurological development. At physical examination his weight was 24 kg (0.06 SDS) and h...

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...

Introduction: IGFs (Insulin like growth factors) are important regulators of pancreatic β-cell development, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. Insulin resistance plays a key role in PCOS. Based on these findings, we aimed to investigate IGF1 gene polymorphism in polycystic ovary syndrome ...

Introduction: Wolfram syndrome is characterized by diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy and sensorineural deafness. DM is the first manifestation and optic atrophy also onsets in the first decade of life. The onsets of DI and sensorineural deafness are in the second decade, urinary tract abnormalities are in the third decade and neurologic abnormalities are in the fourth decade respectively. Hypogonadotrophic hypogonadism is a usual manifestation of t...

IntroductionGlucagonoma is an extremely rare type of functional pancreatic neuroendocrine tumor that is characterized by distinctive clinical manifestations such as diabetes mellitus, weight loss, deep vein thrombosis, and necrolytic migratory erythema which represents the hallmark clinical sign of glucagonoma syndrome. Here, we report the case of a 53-year-old male patient who presented with high amilase and lipase levels. In further investigation a pan...

Objective: In differentiated thyroid carcinoma (DTC), TSH suppression with levothyroxine (L-T4) is a standard treatment for reducing tumor recurrence after total thyroidectomy. This study aims to evaluate the effect of long-term TSH suppression on the development of sarcopenia and frailty in elderly patients with DTC.Method: Seventy patients aged 60 years and older with stable TSH levels during the last year and under L-T4 due to DTC were included in the...

Introduction: Superior mesenteric artery (SMA) syndrome is a rare cause of abdominal pain due to proximal intestinal obstruction which is characterized by compression of the third portion of the duodenum secondary to the narrowing of the space between the superior mesenteric artery and aorta. The development of the SMA syndrome is primarily attributed to the loss of the intervening mesenteric fat. Lipodystrophy is a rare clinical syndrome characterized by the loss of adipose t...

Context: Adipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate-limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homeostasis and the atherosclerotic process. Polycystic ovary syndrome (PCOS) is an inflammatory based-metabolic disease.Objective: To ascertain whether circulating a...

Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Methods: Ninety wom...